Compression of structured high-throughput sequencing data.

Large biological datasets are being produced at a rapid pace and create substantial storage challenges, particularly in the domain of high-throughput sequencing (HTS).Most approaches currently used to store HTS data are either unable to quickly adapt to the requirements of new sequencing or analysis methods (because they do not support schema evolu

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Digital quantification of gene expression in sequential breast cancer biopsies reveals activation of an immune response.

Advancements in molecular biology have unveiled multiple breast cancer promoting pathways and potential therapeutic targets.Large randomized clinical trials remain the ultimate means of validating therapeutic efficacy, but they require large cohorts of patients and are lengthy and costly.A useful approach is to conduct a window of opportunity study

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